Arachidonic acid stimulates the production of pro-inflammatory prostaglandins and leucotrienes through COX (cyclogenase) and LOX (liposygenase) enzyme conversion process.
Natural 5-LOX enzyme convert arachidonic acid to 5-HETE ( which can ignite prostate cancer ).
Natural 5-LOX inhibitors: Saw palmetto, ginger, curcumin and boswellia.
Natural COX-2 inhibitors: holy basil, berberine , curcumin, EGCG, ginger, common hop, fish oil, oregano, quercetin, resveratrol, rosemary, Chinese skullcap, vitamins A, E
Natural NF-kB inhibitors: allicin, curcumin, EGCG, genistein, gingko biloba, melatonin, quercetin, resveratrol, silymarin, sulphoraphane, vitamins A, C, E
Carnivorous animals can't readily convert linoleic acid (in plants) to arachidonic acid. Herbivores and humans readily convert linoleic acid to arachidonic acid.
Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase
