Telomere Remodeling with Cyclic Telomerase Activation

Telomere Remodeling with Cyclic Telomerase Activation (Green, YouTube/First Flight Attempts, TA Sciences, Geron, Telomolecular) (7) See Age Transformation for results and tables of model numbers. Run telomerase activation as a square wave with a cycle period of a month,
(1) Two weeks using telomerase activation with astragalosides,
(2) Then two weeks using telomerase inhibitors [81s/TI] not used during the first two weeks.
This procedure is expected to produce telomere elongations of less than 38 base pairs per month, that is, less than 456 base pairs/year. I note that RevGenetics now recommends a two-week cycle for telomerase activation, alternating a telomerase activator like Astral Fruit C (cycloastragenol) or Astral Fruit (astragaloside IV) one week with life-extending telomerease inhibitors including resveratrol, quercetin and other supplements the next week.
About 50-200 telomere base pairs are typically lost per cell division, although antioxidants may reduce the loss rate. Humans have about 50 cell divisions available from the embryonic stage of development, so this procedure may outdistance the aging process, although treatment should continue for years. TA Sciences does as well as the maximum here in blood granulocytes, 230 base pairs during each 3-month telomerase-on pulse in the Patton protocol using TA-65, which is probably cycloastragenol. This corresponds to a rejuvenation rate of about 9 years backwards in time per year, or 0.75 years/month.

2 bottles/month, 5 droppers/day = 14-day supply.

1-Month Supply for Cyclic Activation of Telomerase 3 bottles/month, 6 capsules/day = 15-day supply. Both together amount to about $50.00/month.

(1) Telomerease Activation Phase GAIA Herbs Extra Strength Astragalaus Extract, (formerly available) 77 drops/5 mg of astragalosides, at least 5 mg/day, or regular GAIA Astragalaus extract, 150 drops/5 mg of astrogalosides, at least 5 mg/day, or Terraternal cycloastragenol at 25 mg/day, or Terraternal Astragaloside IV at 100 mg/day or RevGenetics Astral Fruit NF, at least 2 capsules/day (for > 5 mg Cycloastragenol with supplemental Purslane extract, Haritaki, and Astragalus Extract). Perhaps Iron Dragon cycloastragenol is effective at 10 mg/day applied as a topical application to the skin. GAIA made other astragaloside-specific astragalus extracts that were used, including their standard Astragalus Extract and astragalus extract in glycerin. Available astragalus extract pills typically feature 1 mg astragalosides per 250 mg of extract. Since GAIA Herbs changed their formula to something weaker early in 2009, I have substituted 6 x 200 mg/day Solaray Astragalus Root Extract (1200 mg/day) in order to approach 5 mg/day astragalosides during a 15-day turn on period followed by 15 days off. Solaray Astragalus Root Extract at this dose satisfies my toxicology checks, although it is more than Solaray recommends. The lower dose is suitable for activating Interleukin 2 in connection with preventing the common cold, but I suspect it is unsuitable for anti-aging telomerase activation at 200 mg/day. Another alternative uses Herbal Remedies Astragalus 1.25 mg astragalosides per 250 mg cap. Via Nature's Way; Astragalus Extract ( Standardized 0.5% Astragalosides ), Nature's Way - 60 VCapsules, Astragalus, dried extract 250mg (root) 0.5% astragalosides, with Astragalus (root) 250mg. 4 capsules yield 5 mg astragalosides. Recently, I have been using 6 x 200 mg capsules of Solaray Astragalus Extract per day, taken with 5 droppers of Herb Pharm Astragalus Extract in a glass of water and 4-8 x 250 mg capsules of Natural Balance Chitosan to improve bioavailability. It may be useful to take the histone deaceylase inhibitor (HDAC inhibitor) sodium butyrate [Links, Images, Papers, Books, Wikipedia] during the first 15 days to facilitate transcription of hTERT and hTR.

GAIA Herbs Astragalus Extract in Glycerin, 30 drops per 1 mg of astragalosides. For use on the scalp or skin or to replace Herb Pharm Astragalus Extract. In 2010, RevGenetics Astral Fruit NF and Terraternal Astragaloside IV became available about the same time as TA Sciences TA-65. Now we can also obtain cycloastragenol from Iron Dragon (10 mg/dose), Biologix Peptide (10 mg), and as Terraternal Cycloastragenol at 25 mg/cap. Also consider Maximum Telomere Support Astragaloside IV from Medicinal Nutraceutics. These are stronger telomerase activators. Cycloastragenol is the most bioavailable.

I am also considering using Naringin, which extends the half-life of circulating drugs, to increase the time that telomerase activators are available. Since May 2010, I have added 6 x 400 mg capsules of ordinary Solaray Astragalus Membranaceus Root per day, since astragalus root is known to improve astragaloside bioavailability. Recently I take all astragalosides in the evening, taking 6 sprays of Now Foods IGF-1 liposomal spray in the morning and afternoon during the two weeks of telomerase activation [Notes] prior to my two weeks of telomerase inhibition. I decided to experiment with IGF-1 liposomal spray in May 2010 to accelerate telomere growth and rejuvenation. I recently also attempt to put GAIA Herbs Astragalus Extract in glycerin on my scalp, if supplies permit, to rejuvenate hair follicles, as topical astragaloside applications have been observed to work effectively in the long run in restoration of hair that has been lost and in the rejuvenation of hair melanocytes to restore hair color. I seem to see a rejuvenation rate of approximately B = - 5.2 years per year with this approach. I took this with vitamin D, about like Medical Nutraceutics recommends for its Maximum Telomere Support astragaloside IV plus vitamin D approach, but decided to drop it when it looked like Vitamin D might be a telomerase inhibitor. Recently Vince Giuliano pointed out that resveratrol seems to be a telomerase activator for normal cells and a telomerase inhibitor for cancer cells (Ref), so that perhaps it will be useful to take resveratrol all of the time. However, resveratrol is involved in gene silencing by activating SIRT1, acting like a histone deacetylase to inhibit transcription, so I will be using resveratrol conservatively as a telomerase inhibitor for the time being as if it inhibited hTERT. I have also discovered that high-polyphenol diets are associated with telomerase inhibitors created by digestive degradation of polyphenols, so that I am recommending using a low polyphenol diet for 15 days while trying to activate telomerase, then using a high polyphenol diet for the next 15 days of telomerase inhibition in connection with this cyclic program of treatment. 


(1.b) Telomerase Access Refinements The telomere t-loop may be opened to make it accessible to telomerase by phosphorylating tankyrase 1 with insulin using insulin-boosters such as Gymnema Sylvestre, Fenugreek Extract, Fenugreek seeds, or 4-hydroxyisoleucine. This may be amplified somewhat in the presence of dextrose. Tankyrase 1 levels may also be boosted with Niacinamide (Nicotinamide, a form of Vitamin B3). Tankyrase 1 opens the telomere t-loop via telomeric PARP activity that strips the telomere of the telomere closure protein TRF1. Tankyrase 1 uses NAD as a stubstrate in poly(ADP-ribosylation) of TRF1, so NAD supplements [Links] may be useful when applying Tankyrase 1 to enable telomerase access to the telomere. Note that niacinamide elevates NAD substrate levels. Once the loop is open, telomerase can access the telomere to extend it. I propose to use Fenugreek extract with supplemental niacinamide to improve telomerase access to telomeres while using cycloastragenol or astragaloside IV as primary telomerase activators [Index, List]. Alternatively, 4-hydroxyisoleucine and niacinamide (nicotinamide) might be used together as adjuvants to improve telomerase access to telomeres while using cycloastragenol, astragaloside IV, or astragalus extract as primary telomerase activators to lengthen telomeres. All materials should be taken 30-60 minutes prior to an evening workout, which improves heat shock protein levels that help with telomerase assembly and transport. Note that telomerase activators and inhibitors are best applied both internally and topically. For the skin, one might use FGF1 skin cream or some other growth factor skin cream that activates telomerase, or Astragaloside IV skin cream, then follow up during the final two weeks with TGF-beta 1 skin cream, which inhibits telomerase, although it reconstitutes proteins such as collagen in the extracellular matrix. Also note that the telomerase activator IGF-1 [Index] is upregulated by casein (cottage cheese), which should only be taken during the telomerase activator phase of treatment.
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