TA-65
[Links,
Images,
Video,
Papers,
Patents,
Books,
LifeExtension].
TA-65
is a telomerase activator,
also termed Geron GRN-665, now a product of
TA Sciences
[TA Sciences back pages], obtained from an
extract of
Astragalus Membranaceus Root
[81s/6b].
TA-65 is probably cycloastragenol
[TAT2,
Links,
Video],
to be taken 5 mg/day 3 months on, 3 months off for a year,
which may be obtained chemically from
telomerase activator
astragaloside IV
[Links,
Video]
by treatment with a hydrolyzing acid, or otherwise from
astragalosides or
extracts of
Astragalus Membranaceus
(7,
Links,
Video).
(Some sources write that TA-65 is NOT cycloastragenol,
but an astragalus extract.
A 1/08/2011 email source quotes a chemical analysis showing that TA-65 is:
5.47 mg cycloastragenol + 0.27 mg
astragaloside IV + < 0.01 mg
astragenol per serving.)
Recent research shows that TA-65 works better at 20-30 mg/day
[Calvin B. Harley, Weimin Liu, Maria Blasco, Elsa Vera, William H. Andrews, Laura A. Briggs, and
Josheph Raffaele (2011), A Natural
Product Telomerase Activator As Part of a Health Maintenance Program,
Rejuvenation Research, 14(1), 2011].
See the Geron Patent
Compositions
and Methods for Increasing Telomerase Activity
(or the A' alternate-source version Compositions
and Methods for Increasing Telomerase Activity, or
A'') and
Formulations Containing Astragalus
Extracts and Uses Thereof. Also see
Recharge Biomedical/tables of
Expression Profiles of Genes Involved in hTERT Promoter Regulation, which include data for
Sierra Sciences
C0057684 and
TA Sciences TA-65.
The same file has tables of genes upregulated and downregulated by TA-65.
TA-65 therapy may be managed through Recharge Biomedical,
via Telomerase Activation managed by
Al Sears, MD, or
from TA Sciences.
Alternatively, one may take
cycloastragenol with
chitosan
to enhance bioavailability.
Geron's TAT2, which might be TA-65, has been identified as
Cycloastragenol,
CAS Registry no. 84605-18-5.
"TA-65 alone will reduce the percentage
of cells with short telomeres ( < 4 kbp) with minimal effects on mean telomere length..." -
Calvin B. Harley, et.al, 2010.
Note that retinal
pigment epithelial cells
transfected with hTERT plasmids show telomeres
lengthening at 115-255 bp per population doubling, and that BJ foreskin fibroblasts similarly
transfected show a telomere length increase of 340-370 bp per population doubling, the same order
of magnitude (400-460 bp/year telomere growth, corresponding to roughly 1 cell division per year)
originally observed at TA Sciences
in 2007 by Bob Waskom and Greta Blackburn. - From
Andrea G. Bodnar,
Michel Ouellette,
Maria Frolkis,
Shawn E. Holt,
Choy-Pik Chiu,
Gregg B. Morin,
Calvin B. Harley,
Jerry W. Shay,
Serge Lichtsteiner, and
Woodring E. Wright (1998),
Extension
of Life-Span by Introduction of Telomerase into Normal Human Cells,
Science,
vol. 279, 16 January 1998. Tests of TA-65 were also done
on prepared mice. See
Bruno Bernardes de Jesus,
Kerstin Schneeberger,
Elsa Vera,
Agueda Tejera,
Calvin B. Harley, and
Maria A. Blasco (2011),
The
telomerase activator TA-65 enlongates short telomeres and increases health span of adult/old mice without
increasing cancer incidence
(Full Text PDF),
Aging Cell, 22 March 2011.
TA-65 Physicians
[Links,
Images,
Video] include
Al Sears, MD of
Telomerase Activation and Recharge Biomedical Clinic
(Dr Edward Park). See also TA Sciences in New York City.
