[Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage; ORAC scale].
Check telomerase activation with acacia bark extract [Links, Images, Papers, Patents, Books].
"Maasai are intoxicated by the bark and root decoction, said to impart courage, even aphrodisia, and the root is said to cure impotence." - Wikipedia/Acacia nilotica. Shang-Tzen Chang, Jyh-Horng Wu, Sheng-Yang Wang, Pei-Ling Kang, Ning-Sun Yang, and Lie-Fen Shyur (2001), Antioxidant Activity of Extracts from Acacia confusa Bark and Heartwood, J. Agric. Food Chem., 2001, 49 (7), pp 3420–3424. "Acacia Bark has been used medicinally for thousands of years throughout the globe, especially in Australia. Today, it is used mostly for digestive problems such as diarrhea. Acacia Bark is also an astringent with a high tannic acid content that helps to check bleeding, discharge and excess mucous. Recent research has discovered that an extract from this highly astringent herb may block the body's pain triggers." Family: Leguminosae (legume) Botanical: Acacia catechu. Other Common Names: Babool, Indian Gum Arabic, Wattle Bark, Black Wattle, Babul. - Viable-Herbal. Sometimes Acacia bark and/or seeds are extracted for psychedelic DMT (dimethyltryptamine) with ethanol. Acacia Bark Extract contains gallic acid, which is hepatoprotective and an angiogenesis inhibitor. Acacia bark is antimicrobial and an antioxidant. See also Prevention of Cellular Senescence in Mammals by Natural Peptide Complexes, which mentions acacia gum.
DL-Alpha Lipoic Acid
[Index, Index/Alpha Lipoic Acid, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage].
DL-alpha lipoic acid supplies both Dextro- and Levo-rotary optical enantiomers of lipoic acid, an antioxidant (ORAC scale). See Wikipedia/Chirality_(chemistry) [Links/Chirality]. Alpha-lipoic acid is available in R-lipoic acid and S-lipoic acid forms corresponding to Levorotary and Dextrorotary forms of lipoic acid, so that we should probably speak of DL-lipoic acid as a synonymn for alpha-lipoic acid, typically a 50-50 racemic mixture of both R-(D)-lipoic acid and S-(L)-lipoic acid, although the R-lipoic acid form is twice as prevelant in the blood after administration of 50-50 alpha-lipoic acid as S-lipoic acid. Alpha-lipoic acid is also available in reduced form as a mixture of therapeutically useful R-dihydrolipoic acid and S-dihydrolipoic acid, or pure R-dihydrolipoic acid, which may exhibit stability problems. These also correspond to the Dextrorotary (+) and Levorotary (-) optical enantiomers of the molecule. Kumaran S, Savitha S, Anusuya Devi M, Panneerselvam C. (2004), L-carnitine and DL-alpha-lipoic acid reverse the age-related deficit in glutathione redox state in skeletal muscle and heart tissues, Mech Ageing Dev. 2004 Jul;125(7):507-12. Stevens MJ, Obrosova I, Cao X, Van Huysen C, Greene DA (2000), Effects of DL-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy, Diabetes 2000 Jun;49(6):1006-15. Palaniyappan Arivazhagan, Kadirvel Ramanathan, Chinnakkannu Panneerselvam (2001), Effect of DL-alpha-lipoic acid on mitochondrial enzymes in aged rats, Chemico-Biological Interactions Volume 138, Issue 2, 28 November 2001, Pages 189-198. P Arivazhagan, S Shila, S Kumaran, C Panneerselvam (2002), Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and antioxidant enzymes in various brain regions of aged rats, Experimental Gerontology Volume 37, Issue 6, 1 June 2002, Pages 803-811.
Asian Ginseng Root Extract (Panax Ginseng)
[Index/Ginseng, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage].
Check telomerase activation with asian ginseng root extract [Links, Images, Papers, Patents, Books].
Ginsenoside Rh1 was investigated as a small molecule telomerase activator by Geron [81s/6b]. Ginsenoside Rh2 is a small molecule telomerase inhibitor [article]. Perhaps a telomerase-activation procedure based on ginsenosides could be specified using Solaray Korean Ginseng Extract, 535 mg extract/capsule, 26 mg ginsensides/capsule, Rg1/Rg2 ratio = 0.5. However, Korean Red Ginseng Extract is a telomerase inhibitor that decreases telomerase activity in leukemia cells. Ginseng is sometimes tagged as an adaptogen. Note that Panax Ginseng extract has an anticancer effect [Index/Anticancer] on cancers induced with benzopyrene, as in smoking [essay].
Ashwaganda Root Extract (Withania somnifera)
[Index/Ashwagandha, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage].
Check telomerase activation with ashwagandha root extract [Links, Images, Papers, Patents, Books].
Ashwagandha is a stress reliever reducing cortisol levels [Books, LifeExtension] up to 26%, lowers blood sugar, and improves lipid profiles, ups sense of well-being, regenerates axons, dendrites, synapses, re-grows brain, reversing Parkinsonian neurodegeneration [Books], and fights Alzheimer's Disease. Ashwagandha exhibits endogenous antioxidant boosting effects, including elevation of SOD levels. (See ORAC scale). It inhibits many kinds of cancer, and is anti-microbial for Salmonella. "Ashwagandha on chronic administration markedly augmented endogenous antioxidants (GSH, GSHPx, SOD, CAT)" (Ray). [63s]. Recently low catalase levels have been linked to hair greying.
Bacopa Extract (Bacopa Monnieri)
[Index/Bacopa, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage].
Check telomerase activation with bacopa extract [Links, Images, Papers, Patents, Books].
Bacopa is neuroenhancing and improves learning and memory. It has been used to alleviate symptoms of anxiety. It addition, it may increase thyroid hormone (T4) levels. It can increase thyroid hormone T4 levels by over 41% in mice. Bodybuilders use Bacopa Monnieri leaf as a fat-burner, taking it before breakfast at 1-2 grams, and with pre- and post-workout meals at 1-2 grams. Bacopa contains bacopasaponins, including the Bacosides A, which enhance SOD, catalase, and glutathione peroxidase (GPX) endogenous antioxidant activity. Bacopa is described in Indian Ayurvedic medicine [Index] as a brain tonic for enhancing memory, learning, and concentration. Bacosides A in Bacopa are thought to maintain the structural and functional integrity of the mitochondrial membrane by inhibiting excessive lipid peroxidation and creatine kinase, and by improving the activities of ATPases. The Bacosides A also maintain mitochondrial ionic equilibrium. Active components of Bacopa include:
| alkaloids
(brahmine and
herpestine), saponins (d-mannitol and hersaponin, acid A, and monnierin), bacopa saponins (bacosides A, bacosides B, bacopaside II, bacopaside I, bacopaside X, __bacopasaponin C, and bacopaside N2 with minor components bacopasaponin F, __bacopasaponin E, bacopaside N1, bacopaside III, bacopaside IV, and bacopaside V.) flavonoids (luteolin and apigenin), and betulic acid, stigmasterol, and beta-sitosterol. |
Berberine Rhizome Extract (Coptis Chinensis)
[Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage].
Check telomerase activation with berberine rhizome extract [Links, Images, Papers, Patents, Books].
"Berberine may be helpful in maintaining healthy blood sugar and cholesterol levels in those with type 2 diabetes.... Berberine... induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells, and is also useful in treating cervical cancer due to the HPV virus types 16 and 18. See Sutapa Mahata, Alok C Bharti, Shirish Shukla, Abhishek Tyagi, Syed A Husain and Bhudev C Das (2011), Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells, Molecular Cancer, April 15, 2011 (online edition). Berberine is... considered to be useful in treating some diseases of the cardiovascular system, such as hypertension and chronic heart failure (CHF). " - Ray Sahelian/Berberine. Berberine is often presented as an anti-inflammatory, like baicalein, curcumin and hesperidin, and is used for the treatment of diverse chronic inflammatory diseases. Berberine is a telomerase inhibitor that suppresses activation of hTERT. (Perhaps only in cancer cells, check.) Berberine is anticancer and antimicrobial. The effects of berberine in senescence accelerated mice P6 (SAMP6) were investigated to learn whether the alkaloid affects bone mineral density (BMD). Oral administration of berberine (10 mg/kg/day) to senescence-accelerated male and female mice for 22 weeks resulted in an increase in bone mineral density in both sexes. - Ray Sahelian/Berberine.
Bilberry Fruit Extract (Vaccinium myrtillus)
[Index/Bilberries, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage; ORAC scale].
Check telomerase activation with bilberry fruit extract [Links, Images, Papers, Patents, Books].
Bilberries contain anthocyanidins, slow brain aging, improve night vision, and are used to strengthen capillary, vein, and arterial walls to guard against purpura and stroke. [25j]. Note that the antioxidant anthocyanins (glucosides of anthocyanidins) differ from the anthocyanidins by the presence of a sugar in the molecule. Antioxidant bilberries are also a good source of resveratrol.
Black Tea Extract (Camellia sinensis)
[Index/Black Tea, Links/Black Tea Extract, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage, ORAC scale]. Green tea [Images], black tea [Images], and white tea [Images] "are all processed from the same bush called Camellia Sinensis. White tea only uses the finest leaves from each bush and is picked early. The tea leaves and white colored buds are slightly steamed and then mostly sun dried using a minimal amount of processing. Because the tea has been hardly processed it contains high levels of antioxidants.... white tea is 10% more effective than green tea..." Kayla Fioravanti (2011), A Closer Look at White Tea Extract Posted January 13, 2011. White tea fights cancer somewhat better than green tea.
Blueberry Fruit Extract (Vaccinium angustifolium)
[Index/Blueberries, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage, ORAC scale].
Blueberries contain powerful life-extending polyphenols, [Links/Blueberry polyphenols] and SIRT1-activating caloric restriction mimetic and telomerase inhibitor resveratrol, in addition to the resveratrol-related pterostilbene. [25a]. Blueberry polyphenols are anticancer [Links] and counteract metabolic syndrome [Links] and diabetes. Note that metabolic syndrome patients are more prone to suffer from a wide range of cancers, especially colorectal cancer. According a recent article, blueberries
| (1) inhibit
angiogenesis [Index]
creating new tumor blood vessels, (2) impede tumor cancer cell metastasis (spreading), (3) stimulate cancer cell differentiation into less malignant forms. |
Boswellia Fruit Extract (Boswellia serrata)
[Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage].
Boswellia serrata [Wikipedia] is also known as Indian Frankincense. Boswellia gum extract is anti-inflammatory, vascular supporting, and is used to support the structural health of cartilage. It has been used for hundreds of years to treat arthritis. The major constituent is boswellic acid (beta-boswellic acid). It may be anticancer.
Chia Seed Extract (Salvia hispanica)
[Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage].
Check telomerase activation with chia seed extract [Links, Images, Papers, Patents, Books]. Chia seed extract appears to slow down telomere shortening via its anti-inflammatory omega 3 fatty acids.
L-glutathione
[Index/glutathione, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage, ORAC scale].
Grape Seed Extract (Vitis vinifera)
[Index/Grape Seed Extract, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage].
Grape seed extract with calcium promotes bone formation and defeats osteoporosis. Gallic acid from grape seed extract is thought to be anti-proliferative, pro-apoptotic, and anti-angiogenic in acting against prostate cancer. See angiogenesis inhibitors, which include gallic acid. Grape seed extract also contains resveratrol.
Green Tea Extract (Camellia sinensis)
[Index/Green Tea, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage; ORAC scale].
Green tea [Images], black tea [Images], and white tea [Images] "are all processed from the same bush called Camellia Sinensis. White tea only uses the finest leaves from each bush and is picked early. The tea leaves and white colored buds are slightly steamed and then mostly sun dried using a minimal amount of processing. Because the tea has been hardly processed it contains high levels of antioxidants.... white tea is 10% more effective than green tea..." Kayla Fioravanti (2011), A Closer Look at White Tea Extract Posted January 13, 2011. White tea fights cancer somewhat better than green tea.
Harada Fruit Extract (Terminalia Chebula)
[List/Haritaki, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage].
Check telomerase activation with harada fruit extract [Links, Images, Papers, Patents, Books].
Harada Fruit Extract (Haritaki, or Terminalia Chebula) which enhances telomerase activity, is also described as a laxative.
Hawthorn Fruit Extract (Crataegus pinnatifida)
[Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage, ORAC scale].
Check telomerase activation with hawthorne fruit extract [Links, Images, Papers, Patents, Books].
Hawthorn berries contain antioxidant flavonoids. "Hawthorne berries contain a number of antioxidants, including flavonoids and oligomeric procyanidins, which may be responsible for the extract's effects on the heart and blood vessels. In addition, animal research suggests it could play a role in lowering serum cholesterol and protecting arteries from plaque." - Ultimate Fat Burner. "Traditionally, the berries were used to treat heart problems ranging from irregular heartbeat, high blood pressure, chest pain, hardening of the arteries, and heart failure." - University of Maryland Medical Center.
Horny Goat Weed (Epimedium saggittatum)
[Index/Horny Goat Weed, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage].
Check telomerase activation with horny goat weed [Links, Images, Papers, Patents, Books].
Inhibits the enzyme that destroys nitric oxide. Nitric oxide [List] activates telomerase in endothelial progenitor cells.
Maca Root Extract (Lepidium Meyenii)
[Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage].
Check telomerase activation with maca root extract [Links, Images, Papers, Patents, Books].
Lepidium meyenii is radish-like, growing in the Andes in South America at elevations up to 15,000 feet. "For more than two millennia, native Peruvians have used it as food and medicine, to promote endurance and improve energy, vitality, sexual virility and fertility. Human studies with this herb indicate supplementation leads to enhanced sexual desire and...can also partially reverse sexual dysfunction after menopause. Peruvians have used it as food and medicine, to promote endurance and improve energy, vitality, sexual virility and fertility...." - Ray Sahelian/maca. A. F. G. Cicero, S. Piacente, A. Plaza, E. Sala, R. Arletti, C. Pizza (2002), Hexanic Maca extract improves rat sexual performance more effectively than methanolic and chloroformic Maca extracts, Andrologia, Volume 34, Issue 3, pages 177–179, June 2002.
Milk Thistle Extract (Silybum marianum)
[Index/Milk Thistle, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosages].
Milk thistle is a member of the Daisy family (Asteraceae), is an anticancer telomerase inhibitor and can prevent the loss of glutathione, an endogenous antioxidant [Life Extension Magazine, July 2009]. "The seeds of milk thistle have been used by herbalists for 2000 years to treat chronic liver disease and protect the liver against toxins." - Wikipedia/Milk_Thistle. Many of these effects are due to milk thistle's silymarin. Milk thistle's silybinin also protects against lung, prostate, skin, and colon cancer, and against cancer metastasis. See also Silymarin [Index], and Silybinin [Papers, Patents, Books, LifeExtension]. Active ingredients of milk thistle include: Silymarin and silybinin, with silybin A, silybin B, isosilybin A, isosilybin B, silydianin, isosilydianin, silychristin and isosilychristin. See Dhanalakshmi S, Singh RP, Agarwal C, Agarwal R (2002), Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced apoptosis, Oncogene, 2002 March 7; 21(11):1759-67. Music: HAL 9000 sings Daisy, from 2001: A Space Odyssey.
N-acetyl-L-cysteine
[Index/NAC; Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage].
See NAC in heavy-metal & mercury chelation, plus chelation of arsenic, cadmium, and lead, as LEF product, (1), [31s]. NAC is a highly bioavailable form of L-Cysteine, and a powerful antioxidant taken at 600 mg/day to 1800 mg/day that replenishes glutathione (GSH), in addition to being a premier scavenger of heavy metal ions. NAC induces apoptosis in many kinds of cancer cells, and has been useful in reducing corectal polyps [Images] at 600 mg/day to 1200 mg/day. Furthermore, NAC controls obesity-associated insulin resistance arising from the production of inflammatory signaling molecules in fat cells. NAC is also effective against bird flu, inhibiting replication of H5N1 virus and associated expression of pro-inflammatory cytokines, and shows anti-viral effect against influenza and its associated "cell boiling" effects, especially when given with green tea and 1600 mg of arginine. NAC is not available from the diet, and must be taken as a supplement, like acetyl L-Carnitine, a more bioavailable form of L-carnitine synthesized by scientists. It influences gene expression in the reduction of inflammation associated with NF-kappa-B and TNF-alpha, and is effective against acetaminophen (Tylenol) toxicity and acute liver failure, influenza ("3/4 of all flu-related deaths occur in the elderly"), chronic lung diseases ("including emphysema and chronic bronchitis"), cancers, insulin resistance, and gastritis due to H. Pylori ("linked to gastric cancer, the 2nd most frequent cause of cancer death worldwide"). "NAC blocks cancer development at virtually every step in the process, and through multiple mechanisms, making it an important cancer chemopreventive agent." NAC reduces the carcinogenicity of tobacco smoke.
Plantain Leaf Extract (Plantago Major)
[Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage].
Check telomerase activation with plantain leaf extract [Links, Images, Papers, Patents, Books].
"Plantain Leaf Extract has an excellent use in traditional medicine for treating the glandular system, with marked healing to affected lymph and epidermal areas in scrofulous and skin diseases. It is an excellent remedy in kidney and bladder troubles and an effective remedy for poisonous bites and stings, since the poison of fresh stings is extracted rapidly. It is also the best healer of blood poisoning." - Best Botanicals/Plantain-Leaf-Extract Dr R. Gomez-Flores, C. L. Calderon, L. W. Scheibel, P. Tamez-Guerra, C. Rodriguez-Padilla, R. Tamez-Guerra, R. J. Weber (2000), Immunoenhancing properties of Plantago major leaf extract, Phytotherapy Research Volume 14, Issue 8, pages 617–622, December 2000. Anne Berit Samuelsen (2000), The traditional uses, chemical constituents and biological activities of Plantago major L. A review, Journal of Ethnopharmacology, Volume 71, Issues 1-2, July 2000, Pages 1-21. "Abstract: Plantago major L. leaves have been used as a wound healing remedy for centuries in almost all parts of the world and in the treatment of a number of diseases apart from wound healing. These include diseases related to the skin, respiratory organs, digestive organs, reproduction, the circulation, against cancer, for pain relief and against infections. P. major contains biologically active compounds such as polysaccharides, lipids, caffeic acid derivatives, flavonoids, iridoid glycosides and terpenoids. Alkaloids and some organic acids have also been detected. A range of biological activities has been found from plant extracts including wound healing activity, anti-inflammatory, analgesic, antioxidant, weak antibiotic, immuno modulating and antiulcerogenic activity..." Medicines that enhance the immune system and also improve wound healing often turn out to activate telomerase activity, which equips immune cells with more cell division capacity to fight infections.
Pomegranate Fruit Extract (Punica granatum)
[Index/Pomegranate, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage, ORAC scale].
Pomegranates are rich in punicalagins [Links/Punicalagins, Images, Video, Papers, Patents, Books, Patents/Pomegranate, Wikipedia/Punicalagins]. Punicalagins are powerful antioxidants. Pomegranate increases synthesis of nitric oxide (NO), inhibits oxidation of LDL cholesterol, when applied topically, promotes youthfulness in skin, slows PSA (prostate-specific antigen) doubling time (anti-prostate cancer), speeds wound healing when applied topically, inhibits cyclooxygenase(s) and lipoxygenase when applied to skin, increases collagen synthesis by skin fibroblasts, which also synthesize elastin. [LifeExtension, Wikipedia, Links, Books, Books/Pomegranate in NO synthesis, Papers, Links]. Dr. Shiuan Chen at the Division of Tumor Cell Biology at the City of Hope found 10 ellagitannins in pomegranate that can potentially prevent estrogen-responsive breast cancer, and a metabolite of ellagic acid termed urolithin B inhibiting associated breast cancer cell growth. Pomegranates are anticancer. (Dayna Dye, Pomegranate Inhibits Hormone-dependent Breast Cancer Cell Growth, Life Extension Magazine, April 2010.) Note that Pomegranate contains the powerful antioxidant ellagitannin. Pomegranate also upregulates PON-1 (paraoxonase-1), an enzyme required for optimal function of artery-cleansing HDL, and down-regulates nuclear factor kappa beta. (See the Julius Goepp article, below, LEF, May 2010.) Recently, Life Extension Magazine (May 2010) has also been heralding Pomegranate Seed Oil [Index] and Pomegranate Flower Extracts [Index].
Quercetin
[Index/Quercetin, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage;
Links/Quercetin in foods; Quercetin solubilities, Quercetin extraction]. Improves resveratrol bioavailability.
Quercetin is potent in gene silencing and in activating the SIRT1 gene, "a sirtuin-activating compound...reported to extend the life span of fruit flies & nematodes", found in grapes, apples, onions, red wine, (0), [113]. See Resveratrol & Quercetin by James South. Quercetin is a small molecule telomerase inhibitor and a small molecule SIRT1 activator, like resveratrol. Quercetin chelates both copper and iron, helping it both oppose the metastasis or spread of cancer via copper and helping it to protect hippocampal mitrochondria against copper and iron, opposing cognitive decline, dementia, and Alzheimer's Disease. See the role of copper in cancer metastasis. Quercetin reduces the expression of an enzyme that produces sorbitol [Images, Books, LibCong, Amazon, Wikipedia, LifeExtension], a sugar alcohol associated with cataracts. Quercetin also increases markers of nitric oxide production and reduces the concentration of a vasoconstricting factor. Finally, quercetin stimulates pancreatic cells [Links] controlling blood glucose levels in diabetics and non-diabetics.
Quercetin improves the biovailability of resveratrol. Lecithin (first isolated from egg yolks, see also soy lecithin and phosphatidylcholine) enhances the bioavailability of polyphenols, including resveratrol and quercetin.
See also Vincent C. J. de Boer, Marcus C. de Goffau, Ilja C. W. Arts, Peter C. H. Hollman, and Jap Keijer (2006), SIRT1 stimulation by polyphenols is affected by their stability and metabolism, Mechanisms of Aging and Development, 127 (2006) 618-627, which was suggested by a correspondent 12/30/2010. The paper focuses on SIRT1 in "HT29" colon cancer cells, and SIRT1 interactions with quercetin, resveratrol, EGCG, and other polyphenols under varying conditions. Check on whether or not (like resveratrol) quercetin phosphorylates existing cytosolic hTERT [Images, Papers, Books].
Red Raspberry Fruit Extract (Rubis ideais)
[Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage].
Red raspberry extract is the best source of ellagic acid, a powerful antioxidant and an anticancer nutraceutical. See ellagic acid [Wikipedia, Links, Images/Ellagic acid supplements, Papers, Patents, Books, LifeExtension]. Ellagic acid is an anti-cancer nutraceutical found in walnuts, pecans, strawberries, cranberries, pomegranates and red raspberry seeds, [25e]. Check: ellagic acid inhibits telomerase activity?
Resveratrol
[Index/Resveratrol, Links, Images, Papers, Patents, Books LifeExtension; sources, toxicity, side effects, dosage, ORAC scale].
Resveratrol phosphorylates cytoplasmic hTERT for import into the cellular nucleus to increase telomerase activity. Activates SIRT1 to compress chromatin for gene silencing, however, which tends to inhibit hTERT transcription. Resveratrol is also described as an antioxidant.
Shilajit Extract
[Index/Shilajit, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage].
Shilajit is an organic compound shown to double levels of CoQ10 in the mitochondria. The active components of shilajit relevant to mitochondrial defense are fulvic acid and dibenzo-a-pyrones (DBPs). Shilajit also produces higher levels of endogenous antioxidants such as SOD, catalase, and glutathione peroxidase in brain tissue, like Ashwagandha and Huperzine A do, and reduces levels of acetylcholinesterase destroying acetylcholine. (Julius Goepp MD, Reverse Mitochondrial Damage, LEF, Feb 2010).
Turmeric Root Extract (Curcuma longa)
[Index/Curcumin, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage, ORAC scale].
Curcumin [List] from turmeric is a telomerase inhibitor and anticancer nutraceutical that may be capable of stalling telomere growth in normal cells as well as in cancer cells. Curcumin is an antioxidant, and thus preserves telomere length against DNA damage.
Velvet Bean Extract (Mucuna Pruriens)
[Index/Mucuna Pruriens Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage, ORAC].
Check telomerase activation with velvet bean extract [Links, Images, Papers, Patents, Books].
Velvet bean extract improves dopamine and HGH levels. HGH improves both transcription of hTERT and phosphorylation of hTERT. (Gomez-Garcia, et. al, 2005).
Vitamin C
[Index/Vitamin C, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage, ORAC scale].
20 mg. 30%. Vitamin C is an antioxidant reducing DNA damage to telomeres. It is also required for the synthesis of collagen.
Vitamin B12
[Index/Vitamin B12, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage].
20 mcg. 330%. Vitamin B12 is a methyl donor for gene silencing, which inhibits hTERT transcription and other transcriptional activity, as methylation is used to switch off genes, although frequently under the direction of specific methyltransferases. Check: Is Vitamin B12 a telomerase inhibitor? Note that vitamin B12 improves nerve conduction velocity and is a component of homocysteine shields.
Vitamin E
[Index/Vitamin E, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage, ORAC scale].
15 IU. 50%. Vitamin E is an antioxidant reducing damage to telomeres.
White Tea Extract (Camellia sinensis)
[Index/White Tea, Links, Images, Papers, Patents, Books, LifeExtension; sources, toxicity, side effects, dosage, ORAC scale].
Green tea [Images], black tea [Images], and white tea [Images] "are all processed from the same bush called Camellia Sinensis. White tea only uses the finest leaves from each bush and is picked early. The tea leaves and white colored buds are slightly steamed and then mostly sun dried using a minimal amount of processing. Because the tea has been hardly processed it contains high levels of antioxidants.... white tea is 10% more effective than green tea..." Kayla Fioravanti (2011), A Closer Look at White Tea Extract Posted January 13, 2011. White tea fights cancer somewhat better than green tea. White tea is popular in antiaging cosmetics, where it is used to protect skin and immune cells due to its antioxidant properties. Camellia Sinensis provides EGCG, an antioxidant and telomerase inhibitor, in teas.
